gallbladder disorders
Conditions
Interventions
Etomidate:Total intravenous anesthesia with etomidate
Propofol:Total intravenous anesthesia with propofol
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age range: 18 to 65 years old; 2) Day surgery; 3) Scheduled to undergo laparoscopic cholecystectomy under general anesthesia; 4) Agree to participate in this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Refusal to participate in this study; 2) ASA classification grade III or above; 3) BMI less than 18.5 kg/m² or greater than 29.9 kg/m²; 4) History of chronic analgesic or sedative drug use, including benzodiazepines, alcohol abuse, or allergy to etomidate or propofol; 5) History of insomnia; 6) Severe preoperative cognitive impairment with MMSE score = 20; 7) Inability to understand assessment scales such as QoR-15; 8) Inability to self-care prior to surgery; 9) Cerebrovascular accident, myocardial infarction, or unstable angina within the last 3 months; severe hepatic or renal dysfunction; preoperative blood pressure = 180 mmHg; 10)Undergone surgery within the last 3 months; participation in another study within the last 30 days; 11) Patients who have taken hormones or other immunosuppressive drugs for more than 10 days in the past 6 months, or have a history of adrenal cortex suppression or immune system disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital complications (comprehensive complications);Response time to verbal commands and extubation time;PACU stay time;Patient self-reported pain, anesthesia comfort, and satisfaction;Injection pain;Time to loss of consciousness;Incidence of hypertension and hypotension;Incidence of Delirium;Incidence of PONV;Severity of nausea;Frequency of vomiting;PAIN;Intraoperative awareness;Incidence OF COMPLICATIONS;The long-term quality of life;Myoclonus; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
Nanjing Drum Tower Hospital
Outcome results
None listed