Total knee replacement
Conditions
Interventions
Bupivacaine group:0.25% bupivacaine 100mg (40ml) was divided into two groups of 20ml liquid. Ultrasound-guided nerve block was performed 10min before anesthesia. Ultrasound-guided cryptographic nerve
Sponsors
The Northern Theater Command General Hospital of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Primary unilateral total knee arthroplasty was performed ?ASA grade I-III
Exclusion criteria
Exclusion criteria: ? Emergency surgery; ? Combined with uncontrolled hypertension, diabetes, etc.; ? Have a history of neurological diseases such as stroke and epilepsy; Combined with serious liver and kidney function damage, heart failure, malignant tumor and other serious diseases; (5) Long-term use of opioids; ? Infection at the nerve block site; ? Patients can not cooperate with research, such as: language understanding, mental illness, etc Those who are allergic to the drugs used in this study; ? Participated in EXPAREL study before ? Currently pregnant, breastfeeding or trying to become pregnant Diabetic neuropathy, coagulation or bleeding disorders, severe peripheral vascular diseases, renal insufficiency, liver dysfunction, or other contraindications ? participated in other clinical trials within 3 months prior to study inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue VAS was used ;Area under the NRS pain intensity curve ;total number of compressions within 72h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of first compression of the analgesic pump;Postoperative pain scoresVAS;Duration of first opioid (oxycodone) use, total use, and remedial analgesia rate;Total opioid consumption;The first straight leg elevation time, the first time to get out of bed, the first walking distance, and the postoperative hospitalization time;Incidence of falls;Incidence of toxicity in cardiovascular and central nervous system disorders;Incidence of neurological toxicity;Motor ability recovery; | — |
Countries
China
Contacts
Public ContactYugang DIAO
The Northern Theater Command General Hospital of the People's Liberation Army
Outcome results
None listed