Lung injury
Conditions
Interventions
Individualized PEEP group:Static lung compliance-guided positive end-expiratory pressure
Fixed PEEP group:PEEP=4cmH2O
Sponsors
Department of Anesthesiology, Shandong Cancer Hospital and Institute A?liated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) For elective laparoscopic surgery in trendelenburg position and duration of surgeru>=2 hour (2) ASA grade I-III patients (3) Body mass index,(BMI) 19-28kg/m2 (4) 65-80 years old
Exclusion criteria
Exclusion criteria: 1. Preoperative pulmonary inflammation, pulmonary edema, emphysema, chronic obstructive pulmonary disease or diaphragmatic dysfunction;OSAHS, asthma; 2. Previous history of intrathoracic surgery or cardiopulmonary injury; 3. Severe cardiovascular diseases (such as myocardial infarction, heart failure, malignant arrhythmia, etc.) , renal diseases, liver diseases, diseases (serum total bilirubin >=2 mg/dl)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung ultrasound scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;CC-16;Sufactant protein A;Respiratory mechanic ; | — |
Countries
China
Contacts
Public ContactXiuqin Wang
Shandong Cancer Hospital and Institute A?liated to Shandong First Medical University (Shandong Academy of Medical Science)
Outcome results
None listed