end-stage renal disease
Conditions
Interventions
Sponsors
the Affiliated Wuxi People's Hospital to Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Meet KDIGO criteria for diagnosis and staging of chronic kidney disease 2.Duration of continuous ambulatory peritoneal dialysis treatment =3 months 3.Age 18-75 years old, gender unlimited 4.Willing to participate with full and informed consent
Exclusion criteria
Exclusion criteria: 1. Patients who have taken antibiotics, glucocorticoids or other immunosuppressants, foods and drugs containing probiotics and prebiotics within the past 2 months; 2. Patients with unstable vital signs and condition; 3. Patients who Complicated with active malignant tumor, infection, cardiovascular and cerebrovascular events in the past 3 months; 4. Patients with a history of gastrointestinal bleeding, irritable bowel syndrome, Crohn's disease or ulcerative colitis, or a history of gastrointestinal surgery; 5. Patients with severe malnutrition: Subjective Overall Assessment (SGA) > 15; Anemia Hb< 90g/L 6. Pregnant or lactating women; 7. Patients are unable, unwilling, or do not agree to comply with study requirements, including lifestyle adjustments, follow-up visits, and subject duties; 8. Patients with a history of kidney transplantation or who plan to receive kidney transplantation within 6 months; 9. Patients are allergic or intolerant to the ingredients of the experimental probiotic products; 10.Patients are in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| protein-bound uremic toxins ;intestinal microflora ;SF - 36 scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine;blood biochemistry;inflammatory marks;SGA score; | — |
Countries
China
Contacts
Public ContactWang liang
The Affiliated Wuxi People's Hospital to Nanjing Medical University
Outcome results
None listed