Periprosthetic joint infection
Conditions
Interventions
Catheter group:Using catheter after DAIR operation
None-catheter group:Without using catheter after DAIR operation
Sponsors
The first affliated hospital, Xinjiang medical university
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old, gender is not limited; (2) Meet the diagnostic criteria for DAIR surgery of artificial knee joint; (3) Receiving knee DAIR surgery; (4) Voluntary and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with chronic PJI infection undergoing total knee revision; (2) Patients with severe knee joint infection who cannot undergo artificial joint replacement; (3) Progressive renal insufficiency (stage 4 and above) or glomerular filtration rate less than 30ml/min; (4) periprosthesis infection after multiple joint replacement; (5) Active infection at the site of intravenous or joint injection; (6) long-term use of anticoagulants or antiplatelet drugs due to other diseases; (7) Have sepsis or positive blood culture within the last 30 days; (8) Radiotherapy and chemotherapy are required due to neoplastic diseases; (9) Receiving systemic glucocorticoid therapy (prednisone > 10mg/ day or equivalent hormone medication); (10) severe immunodeficiency diseases (such as stage 3 HIV, sickle cell anemia, splenectomy, etc.); (11) Have a history of drug abuse; (12) Treatment of bone marrow or other transplants with immunosuppressive drugs; (13) Pregnant, parturient and lactating women; (14) Participating in other clinical trials; (15) Researchers believe that other reasons are not appropriate for clinical trial participants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| infection control rate;Time between infection recurrence;Re-operation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| X-ray;American knee score (AKS);Rednes, Edema, Ecchymosis, Discharge, Approximation of wound edges score (REEDA score) ;Visual analogue scale score (VAS);Red blood routine;liver function;kidney function;erythrocyte sedimentation rate (ESR);C-reactive protein (CRP);Synovial fluid white blood count (SF-WBC);synovial fluid polymorphycyte neuclear cell (PMN)%; | — |
Countries
China
Contacts
Public ContactBoyong Xu
Department of Joint Surgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People 's Republic of China
Outcome results
None listed