Mild cognitive impairment in elderly with coronary heart disease
Conditions
Interventions
The treatment group :Tongxin Yinao granules+ conventional Western medicine treatment
The control group :Tongxin Yinao granules placebo + conventional Western medicine treatment
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Conforms to 2023 by the AHA/ACC/ACCP/ASPC/NLA/PCNA management guidelines for patients with chronic coronary artery disease: clinical practice guidelines, the American heart association/American college of cardiology joint committee report the diagnostic criteria of coronary heart disease; (2) Meet the diagnostic criteria for mild cognitive impairment: Refer to China's 2018 Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment: Diagnostic criteria for the diagnosis and treatment of mild cognitive impairment; (3) According to the Guiding Principles for Clinical Research of New Chinese Medicine and the diagnostic criteria for kidney deficiency and blood stasis syndrome, the TCM syndrome diagnosis criteria for MCI kidney deficiency and blood stasis syndrome in elderly coronary heart disease were formulated, which met the criteria for syndrome differentiation of kidney deficiency and blood stasis syndrome; (4) Age =65 years old and =80 years old, gender is not limited; (5) Visual and auditory resolution is relatively intact, and can cooperate with the completion of relevant assessments; (6) Agreed to participate in the study, the patient signed the informed consent; (7) Those who did not participate in other clinical trials.
Exclusion criteria
Exclusion criteria: (1) Dementia of various causes diagnosed by the DSM-IV criteria for dementia, a history of severe head trauma with persistent neurological deficits or known brain structural abnormalities; (2) persons with previous mental disorders, drug or alcohol abuse or dependence within the previous 5 years; (3) Patients who took Chinese medicines, anticholinergics, anticonvulsants, antiparkinsonics, excitatory drugs, cholinergics, antipsychotics, such as Donepezil, cabalatin, galantamine, huperzine A, which have the effect of tonifying kidney and essence, within 1 month before the test; (4) Patients with severe liver and kidney dysfunction, such as ALT or AST more than 1.5 times the normal value, or creatinine and urea nitrogen more than 1.2 times the normal range, creatinine clearance CrCl < 60 mL/min, coagulation dysfunction and other patients who are not expected to complete the test; (5) Those who have been allergic to the test drug or intolerant to the drug.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score ;Brachi-ankle pulse wave propagation velocity;Ankle-brachial index;Carotid artery endo-media thickness;Peronea-1 in serum;FGF-21;NLR; | — |
Primary
| Measure | Time frame |
|---|---|
| MoCA Score;Seattle Angina Questionnaire Score; | — |
Countries
China
Contacts
Public ContactFengqin Xu
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed