Skip to content

Effects of LINC00476 targeting BAG2 to regulate SLIT3/ROBO1 on vasculogenic-osteogenic coupling in osteoporosis and the effect of herbal intervention

Effects of LINC00476 targeting BAG2 to regulate SLIT3/ROBO1 on vasculogenic-osteogenic coupling in osteoporosis and the effect of herbal intervention

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400087384
Enrollment
Unknown
Registered
2024-07-26
Start date
2024-08-01
Completion date
Unknown
Last updated
2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoporosis

Interventions

Non osteoporosis group:None

Sponsors

The Third Affiliated Hospital of Guangzhou University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: Bone tissue collection: Patients aged between 30-75 years who meet the surgical indications for lumbar fusion internal fixation, vertebral body shaping, and anterior/posterior cross reconstruction require the aforementioned surgical treatments. Blood sample collection: Age between 30-75 years old, regardless of gender.

Exclusion criteria

Exclusion criteria: (1) Secondary osteoporosis caused by other diseases; (2) Patients with mental illness and dementia who cannot cooperate in completing the questionnaire; (3) Patients who have used steroids or calcitonin within six months and have continuously used bisphosphonates within the past year; (4) There are other reasons that affect bone density measurement; (5) Suffering from rheumatoid arthritis; (6) Suffering from bone tumors or Paget's disease (malocclusion); (7) Have had their ovaries removed before;

Design outcomes

Primary

MeasureTime frame
Long Intergenic Non-Protein Coding RNA 476;Slit Guidance Ligand 3(SLIT3);

Secondary

MeasureTime frame
BCL2 Associated Athanogene 2(Bag2);Bone turnover indicators;

Countries

China

Contacts

Public ContactLei Wan

The Third Affiliated Hospital of Guangzhou University of Chinese Medicine

gzwl802@163.com+86 134 3035 3046

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026