diabetic nephropathy
Conditions
Interventions
treatment group:In the treatment group, patients received both valsartan capsules and the YishenJianpiHuazhuo formula. Valsartan capsules were administered at a daily dosage of 80 mg per dose, taken o
control group:the control group received a combination of valsartan capsules and a placebo. Valsartan capsules were administered at a daily dosage of 80 mg per dose, taken orally once daily. The treat
Sponsors
Changchun University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Between the ages of 20 and 80, regardless of gender; (2) Meets the diagnostic and staging criteria for DN, with stages ranging from DN III to IV; (3) Traditional Chinese medicine syndrome differentiation belongs to spleen and kidney qi deficiency, accompanied by dampness and turbidity; (4) Urinary microalbumin/creatinine>3.39mg/mmol/L, or urinary microalbumin>30mg/L; (5) Those who can complete the entire course of treatment, cooperate with treatment and follow-up; (6) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Pregnant and lactating women; (2) Difficult to control hypertension and high blood sugar; (3) Patients with acute heart failure, acute renal failure, or the need for emergency hemodialysis; (4) Individuals who have recently merged with acute cardiovascular and cerebrovascular events; (5) Patients with mental disorders and abnormalities who cannot cooperate; (6) Those who have not signed the "Patient Informed Consent Form".
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine (Scr) level;Blood urea nitrogen (BUN) level;Urinary total protein (UTP) level;Urinary albumin to creatinine ratio (UACR) level;Creatinine clearance;Estimated glomerular filtration rate (eGFR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose (FBG) level;Postprandial blood glucose (PBG) level;Fasting insulin (FINS) level;Glycated hemoglobin (HbA1C) level;Total cholesterol (TC) level;Triglycerides (TG) level;High-density lipoprotein cholesterol (HDL-C) level;Low-density lipoprotein cholesterol (LDL-C) level;Malondialdehyde (MDA) level;Superoxide dismutase (SOD) level;Glutathione peroxidase (GSH-Px) level;CD4+ level;CD8+ level;CD4+/CD8+ level;Interleukin-6 (IL-6) level;Interleukin-8 (IL-8) level;Tumor necrosis factor-alpha (TNF-a) level;C-reactive protein (CRP) level; | — |
Countries
China
Contacts
Public ContactHongjiajing
Changchun University of Chinese Medicine
Outcome results
None listed