Post-stroke Cognitive Impairment
Conditions
Interventions
Low frequency group:The stimulation frequency was 1 Hz, the stimulation site was the dorsolateral region of the healthy prefrontal lobe, and the stimulation time was 20 minutes
High frequency group 1:The stimulation frequency was 5 Hz, the stimulation site was the dorsolateral region of the affected prefrontal lobe, and the stimulation time was 20 minutes
High frequency group 2:The stimulation frequency was 10 Hz, the stimulation site was the dorsolateral region of the affected prefrontal lobe, and the stimulation time was 20 minutes
Combined group 1:Firstly, stimulate the dorsolateral prefrontal cortex on the affected side with a high frequency of 5 Hz for 10 minutes, and then stimulate the dorsolateral prefrontal cortex on the u
Combined group 2:Firstly, stimulate the dorsolateral prefrontal cortex on the affected side with a high frequency of 10 Hz for 10 minutes, and then stimulate the dorsolateral prefrontal cortex on the
Blank control group:Give conventional medical treatment and rehabilitation
treatment.
Sponsors
First Affiliated Hospital Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1)Have a clear history of stroke and meet the diagnostic criteria for stroke; (2)The presence of lesions confirmed by cranial CT or MRI; (3) Aged 18-75 years old, with initial, unilateral onset or previous onset but without neurological dysfunction,disease duration <3 months; (4)There is cognitive impairment, with a moderate cognitive impairment score of 14-20 on the MMSE and a MoCA score of <26 minutes; (5) No serious visual or hearing impairment, and able to cooperate with relevant assessments and testing; (6)No significant cognitive impairment or history of alcohol abuse before the onset of the disease; (7)The patient or his/her family members signed the informed consent form and were approved by the hospital ethics committee.
Exclusion criteria
Exclusion criteria: (1)Severe dysfunction of heart, lung, liver, kidney and other vital organs; (2)Unstable condition, with new infarction or hemorrhage during the treatment process; (3)Having metal implants, pacemakers, or skull defects in the body; (4)History of using drugs that alter cortical excitability; (5)Individuals or families with a history of epilepsy or mental illness; (6)Being unable to cooperate with treatment as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE score;Montreal Cognitive Assessment, MoCA score;Auditory event-related potential P300 MS;Functional Near-Infrared Spectroscopy (fNIRS) ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Enzyme linked immunosorbent assay (ELISA) ; | — |
Countries
China
Contacts
Public ContactQi Feng
First Affiliated Hospital Xi'an Jiaotong University
Outcome results
None listed