subjective cognitive decline
Conditions
Interventions
Intervention group:High-definition transcranial alternating current stimulation (HD-tACS) at 40Hz with an intensity of 1.5mA, targeting the left dorsolateral prefrontal cortex (DLPFC), administered fo
Control group:the stimulator have a built-in placebo mode
electric current ramp up/down at the beginning and the end of sham stimulation in 30 s, while the rest of the session follows the same protocol as the intervention group.
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age between 50-85 years old. 2.Meet the diagnostic criteria for subjective cognitive decline. 3.Have a minimum education level of junior high school or above, with the required abilities in listening, speaking, reading, writing, and comprehension for this study. 4.Sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Presence of unstable systemic diseases or organ failure. 2.Any disease that causes cognitive decline, including Alzheimer's disease, vascular dementia, Parkinson's disease, epilepsy, etc. 3.Substance abuse (illegal drugs or alcohol, tobacco, etc.). 4.History of or currently undergoing electrical stimulation or other neuromodulation techniques. 5.Individuals with implanted pacemakers, cochlear implants, intracranial metal implants or devices. 6.Participation in other clinical trials simultaneously.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA-Beijing; | — |
Secondary
| Measure | Time frame |
|---|---|
| auditory vocabulary learning test of Huashan version ;Wechsler Memory Scale - Logical Memory Subscale;n-back;EEG; | — |
Countries
China
Contacts
Public ContactXiao Lu
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed