Cervical cancer
Conditions
Interventions
Experimental group:Pegylated Recombinant Human Granulocyte Colony-Stimulating Factor in combination with Active Bone Marrow Protection
Control group:Active Bone Marrow Protection
Sponsors
The Second People's Hospital of Yibin City
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years old; 2. Pathologically confirmed cervical cancer,FIGO staging locally advanced cervical cancer (1B2/2A2/2B and above); 3. ECOG performance status 0 - 1; 4. More than the expected survival time in One year; 5. WBC=4×10^9/L, ANC=2×10^9/L Hemoglobin=110g/L, Platelets =100×10^9/L; Bilirubin <=2*ULN; ALT and AST <=2.5*ULN; BUN <=1.5*ULN; Creatinine<=1.5*ULN; 6. Signed study-specific informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients currently or previously receiving systemic chemotherapy or pelvic radiotherapy. 2. Patients with any confirmed diseases causing peripheral blood cell abnormalities. 3. Patients with active infectious diseases. 4. Patients with a history of mental illness. 5. Patients with a history of severe cardiovascular and cerebrovascular diseases, HIV, etc. 6. Pregnant and lactating women. 7. Patients with tumor invasion of the bladder and rectum, assessed by the study to be at risk of perforation. 8. Patients deemed unsuitable for participation in this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutropenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Leukopenia;Anemia;Thrombocytopenia;Duration of Severe Neutropenia;Number of Delays or Interruptions in Chemotherapy Cycles;Incidence of Febrile Neutropenia;Quality of Life; | — |
Countries
China
Contacts
Public ContactShanbing Wang
The Second People's Hospital of Yibin City
Outcome results
None listed