Chronic obstructive pulmonary disease
Conditions
Interventions
Experimental group (HFNC group):The patient received HFNC immediately after extubation.
Control group (NIV):The patient received NIV immediately after extubation.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Patients with COPD who meet the criteria of global initiative for chronic obstructive lung disease (GLOD) standard of patients with COPD (2) Age > 65 years old (3) Respiratory failure is caused by bronchial or lung infection and meets the criteria for pulmonary infection control window
Exclusion criteria
Exclusion criteria: (1) Patients with tracheotomy (2) Accompanied by serious dysfunction of other organs, such as heart, brain, kidney and liver failure (3) There are contraindications to NIV, such as esophageal surgery in recent esophageal patients, facial trauma/postoperative/malformation (4) Poor prognosis or palliative care is expected in the short term (5) Unable to obtain informed consent from family members/individuals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reintubation rate 72 hours and 7 days after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment failure rate (including reintubation rate and replacement of respiratory support);Vital signs and arterial blood gas;Patient compliance and comfort scores;Duration of respiratory support after extubation;Adverse event;Patient sleep quality score;Use of sedative and analgesic drugs after extubation;Incidence of post-extubation delirium;Prognosis: 28-day mortality rate, ICU stay and ICU death rate, hospital stay and hospital death rate, mechanical ventilation time of survivors, tracheotomy rate; | — |
Countries
China
Contacts
Public ContactGuopeng Liang
West China Hospital, Sichuan University
Outcome results
None listed