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Evaluation of the Efficacy and Safety of Modified Total Mesorectal Excision Combined with Mesenteric Pelvic Floor Plombage in Improving Low Anterior Resection Syndrome after Rectal Cancer Surgery: A Prospective, Multicenter, Single-Arm Clinical Trial

Evaluation of the Efficacy and Safety of Modified Total Mesorectal Excision Combined with Mesenteric Pelvic Floor Plombage in Improving Low Anterior Resection Syndrome after Rectal Cancer Surgery: A Prospective, Multicenter, Single-Arm Clinical Trial

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087287
Enrollment
Unknown
Registered
2024-07-24
Start date
2024-10-18
Completion date
Unknown
Last updated
2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rectal cancer

Interventions

Surgery Group:Laparoscopic radical resection of rectal cancer (iTME+ left hemicolic artery preservation + mesentery pelvic floor filling)

Sponsors

Zhujiang Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The pathological type was rectal adenocarcinoma 2. The distance between the tumor and the anal edge was less than 10cm or the tumor was located at or below the peritoneal reflection 3. Meet the indications of TME for rectal cancer (preoperative evaluation can achieve R0 resection and unified preservation of the left hemicolon artery, with or without ileostomy); Patients who underwent transanal specimen extraction were included 4. Patients voluntarily participated in this study and signed informed consent 5. Age above 18 years old and age below 75 years old 6. Patients eligible for surgery based on American Medical Association anesthesiologist class I-III 7. The patient was suitable for left colic artery preservation surgery

Exclusion criteria

Exclusion criteria: 1. previous history of colorectal cancer 2. Distant metastasis 3. Complicated with intestinal obstruction, intestinal perforation, intestinal bleeding and other emergencies 4. Patients who were unable to undergo iTME surgery or could not achieve radical resection by preoperative evaluation 5. Patients after neoadjuvant chemoradiotherapy

Design outcomes

Primary

MeasureTime frame
Incidence and classification of low anterior resection syndrome (LARS);

Secondary

MeasureTime frame
Ianastomotic leakage/stenosis/bleeding;Intestinal obstruction;Pelvic bleeding/infection;Duration of surgery;Time out of bed after surgery;Postoperative farting time;Time to first postoperative fluid intake;Date of discharge;Postoperative Functional Assessment;Quality of life assessment;

Countries

China

Contacts

Public ContactCui Chunhui

Zhujiang Hospital, Southern Medical University

drcuich@163.com+86 135 7054 1388

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 7, 2026