Herpes zoster
Conditions
Interventions
Control Group:Standard Antiviral Therapy, 500 mg of famciclovir 3 times daily
Intervention Group:Standard Antiviral Therapy + Ultrasound-Guided Parathoracic Injection of Dexamethasone Palmitate Emulsion with Ropivacaine ()5ml mixture,
The mixture consists of 0.2% ropivacaine an
Sponsors
The Second Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 50 years and over, with a diagnosis of thoracic herpes zoster; (2) Disease duration =4 points (baseline pain intensity is the mean of the average pain intensity score within 24 hours before randomization).;(4) Patients with a first episode of herpes zoster who have not received any other interventions.
Exclusion criteria
Exclusion criteria: (1) Special types of herpes zoster infection: Patients with disseminated herpes zoster or combined with herpes zoster at other locations. (2) Puncture Risks: Patients Systemic infections, coagulation dysfunction, ongoing anticoagulant/antiplatelet therapy, infections at the puncture site, or thoracic spine abnormalities affecting ultrasound guidance. (3) Special Populations: Pregnant or lactating women, individuals with immunodeficiency, severe cardiovascular, cerebrovascular, respiratory diseases, or other serious systemic conditions that impede treatment cooperation, and patients with mental illness. (4) Medication Allergies: Patients with allergies to treatment-related drugs (e.g.steroid medications, famciclovir, gabapentin, pregabalin, NSAIDs, tramadol) or contraindications for nerve block therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence Rate of Postherpetic Neuralgia (PHN); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity;Sleep Quality;Quality of Life Score;Pain Characteristics;Average Weekly Analgesic Dosage and Name;Levels of Inflammatory Markers;Adverse events and safety assessment; | — |
Countries
China
Contacts
Public ContactRuilin He
The Second Affiliated Hospital of Guangxi Medical University
Outcome results
None listed