Parkinson's patients with constipation
Conditions
Interventions
control:no
Intervention Group 1:Bacillus coagulans tablets (oral, first 6 tablets, then 3 tablets, 3 times a day, 350 mg per tablet, containing not less than 5.0 × 107 CFU/g of live Bacillus coagulans), for 2 we
Intervention Group 2:Bacillus coagulans powder (Oral, 2 bags at a time, 3 times a day, containing not less than 1.0 × 109 CFU/g of live Bacillus coagulans), for 2 weeks (14 days).
Sponsors
Jiujiang University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) All patients met the diagnostic criteria for primary Parkinson's disease; (2) All patients met the Rome IV diagnostic criteria for functional constipation; (3) The symptoms of constipation were severe and affected the patients' quality of life; (4) Hoehn-Yahr stage 1-5 patients; (5) Age greater than 18 years old and less than 80 years old; (6) The patients gave informed consent and participated in the study.
Exclusion criteria
Exclusion criteria: (1) Patients with probiotic allergy; (2) Patients who have been treated with other medications for constipation within 30 days prior to enrollment; (3) Patients who used antibiotics or supplemented probiotics three months prior to baseline sampling and had poor compliance; (4) Secondary constipation and drug-induced constipation with clear causes; (5) Individuals who have had acute gastrointestinal diseases or surgical procedures within the past three months; (6) Combined with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney, respiratory, and hematopoietic systems, malignant tumors, and/or other progressive underlying diseases; Individuals with severe cognitive impairment and other serious neurological disorders; (7) Pregnant, lactating, and childbearing women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weekly Number of spontaneous complete bowel movements (SCBM);Gastrointestinal Symptom Rating Score (Wexner Constipation Rating Scale (Wexner) Score/Cleveland Constipation Scoring System (CSS);Bristol Stool Form Scale (BSFS);Patient with Constipation Quality of Life Scale (PAC-QOL) Score;Parkinson's Disease Patient Quality of Life Questionnaire (PDQ-39) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease severity score (motor and non-motor symptoms; clarification of the effect of live Bacillus coagulans on motor symptoms in patients with Parkinson's disease with the help of evaluation tools such as scales UPDRS Part III);Hamilton Anxiety Inventory;Depression Scale;MMSE;Impact of MoCA; | — |
Countries
China
Contacts
Public ContactShuhua Cheng
Jiujiang University Affiliated Hospital
Outcome results
None listed