Postoperative delirium
Conditions
Interventions
Sevoflurane group:Patients were inhaled with 2%-5% sevoflurane and received remifentanil 6-12ug/kg/h intravenously to maintain anesthesia
Propofol group:Patients received propofol 4-12mg/kg/h and remifentanil 6-12ug/kg/h intravenously to maintain anesthesia
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
Female
Age
65 Years to 86 Years
Inclusion criteria
Inclusion criteria: 1. The patients who received total knee arthroplasty; 2. Patients aged over 65 years; 3. Female; 4. Patients with ASA classification II-III 5. BMI (Body mass index) : 18.5-27.9kg/m2; 6. Patients who scheduled for the first surgery of the day; 7. Patients and their family members who have written consent before enrolment.
Exclusion criteria
Exclusion criteria: 1. Those who have severe hypertension and untreated before operation, history of diabetes, Cardiovascular and cerebrovascular diseases, endocrine system diseases, hyperlipidemia; 2. Patients with severe hepatic and renal insufficiency; 3. Those who have a history of gastrointestinal tract surgery before operation, and those with inflammatory bowel disease and functional dyspepsia; 4. Those who have a history of chemotherapy, radiation exposure; 5. Individuals who have recently (within 6 months) received antibiotics or hormone medications; 6.Patients with neuropsychiatric diseases or anxiety, recent or long-term use of sychotropic drug; 7. Those with a score of = 1 on 4AT; 8. Patients with sleep disorders; 9. Patients who have used anticholinergic drugs during surgery; 10. Patients with blood loss >300ml; 11. Receiving surgical patients; 12.Those who refused to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The alpha diversity index of intestinal flora (Shannon index);The alpha diversity index of intestinal flora (Simpson index);The alpha diversity index of intestinal flora (ACE index);The alpha diversity index of intestinal flora (Chao1 index);the relative abundance of intestinal flora at phylum level (Firmicutes);the relative abundance of intestinal flora at phylum level (Bacteroidetes);the relative abundance of intestinal flora at phylum level (Actinobacteria);the relative abundance of intestinal flora at phylum level (Proteobacteria);postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores;First anal exhaust time and defecation time; | — |
Countries
China
Contacts
Public ContactYANG Kun
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed