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Sex-Specific Factors, Cardiovascular Health and Cognitive Aging Cohort in Pingyin County Shandong Province

Cognitive decline in women based on lifetime endogenous estrogen exposure: trajectory and mechanism

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400087254
Enrollment
Unknown
Registered
2024-07-23
Start date
2023-07-01
Completion date
Unknown
Last updated
2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular health and cognitive decline

Interventions

Exposure group (The presence of cardiovascular disease.):NA
Non-exposure group (No cardiovascular disease):NA

Sponsors

Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 70 Years

Inclusion criteria

Inclusion criteria: Permanent residents of sample village in Pingyin County, Jinan; Aged between 45 and 70 years old; Without hearing, vision, or speech communication impairments; Participants and their family members agreed and sign an informed consent form (ICF); Normal cognitive function at baseline.

Exclusion criteria

Exclusion criteria: Individuals with long-term residence registration but have been living elsewhere; Individuals with severe hearing, vision impairments, or other conditions that may affect the examination results; Individuals with severe schizophrenia; Individuals with intellectual disabilities; Individuals with disorders affecting consciousness; Non-cooperative individuals; Individuals already diagnosed with Alzheimer's disease (AD) or other types of dementia or cognitive impairments; Individual who refuses to sign or withdraws their informed consent form (ICF).

Design outcomes

Primary

MeasureTime frame
Cognitive function;Biomarkers for cognitive impairment;Sex hormones;Reproductive factors of women;

Secondary

MeasureTime frame
Sociodemographic indicators;Lifestyle indicators;Medical history;Anthropometric metrics;Blood biochemical indicators;

Countries

China

Contacts

Public ContactDongshan Zhu

School of Public Health, Cheeloo College of Medicine, Shandong University

dongshan.zhu@uq.net.au+86 156 5220 9841

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026