Herpes zoster
Conditions
Interventions
Control Group:Standard Antiviral Therapy
Intervention Group:Ultrasound-Guided Thoracic Paravertebral PRP Injection Therapy
Sponsors
The Second Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed with herpes zoster involving unilateral thoracic nerves (T1-T12); 2. Age = 50 years and disease duration = 2 week; 3. Mean average pain intensity score (11-point NRS) within 24 hours before randomization = 4 points; 4. Agree to participate in this study and be able to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with disseminated herpes zoster or combined with herpes zoster at other locations; 2. Coagulation dysfunction, taking anticoagulant drugs or/and antiplatelet drugs; 3. Systemic infections or infection at the puncture site; 4. Pregnant or lactating women; 5. Patients with immunodeficiency diseases, severe cardiovascular, cerebrovascular, and respiratory diseases, or other serious systemic diseases that prevent cooperation with the treatment; 6. Patients with mental illness; 7. Patients with thoracic spine deformity or a history of thoracic spine surgery that affects ultrasound positioning; 8. Patients who have contraindications for PRP or are allergic to treatment-related drugs such as famciclovir, gabapentin, pregabalin, Nonsteroidal Antiinflammatory Drugs(NSAIDs), and tramadol; 9. Patients with a recent history of other pain management treatments;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence Rate of Postherpetic Neuralgia (PHN); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain characteristics;Skin lesion recovery;Quality of life score;Sleep quality;consumption and name of rescue analgesics;Pain intensity;Adverse events and safety assessment; | — |
Countries
China
Contacts
Public ContactZongbin Jiang
The Second Affiliated Hospital of Guangxi Medical University
Outcome results
None listed