Postoperative sore throat
Conditions
Interventions
Spray saline group:Before intubation, the laryngeal mucosa near the glottis and the posterior pharyngeal wall were sprayed with equal-volume saline with a laryngeal anesthetic tube under visual laryng
Spray magnesium sulfate group:Before intubation, magnesium sulfate (15mg/kg) was sprayed on the throat mucosa near the glottis and the posterior pharyngeal wall with a laryngeal tube under visual lary
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing gynecological surgery; 2. ASA grade I - II; 3. Aged 18 to 65 years old; 4. BMI 18-30kg/?;
Exclusion criteria
Exclusion criteria: 1. Oral ulcer, sore throat, throat mucosa injury, pharyngitis before operation; 2. Preoperative nausea, vomiting, cough, dysphagia; 3. History of laryngeal surgery; 4. Mallampati graded 2 or above; 5. Preoperative hypermagnesia or allergy to magnesium; 6. Recent respiratory infectious diseases; 7. Preoperative hypoalbuminemia; 8. Smoking history; 9. Preoperative nasogastric tube placement; 10. Decompensated heart disease (heart failure, myocardial infarction, severe arrhythmia); 11. Severe respiratory diseases (severe obstructive or restrictive lung disease, respiratory failure); 12. Severe liver dysfunction (serum total bilirubin >= 2mg/dl); 13. Severe renal dysfunction (glomerular filtration rate < 60ml/ (min·1.73m2); 14. Patients receiving chronic treatment with calcium channel blockers or magnesium. 15. Contraindications of magnesium sulfate: acute intestinal bleeding, acute abdomen, pregnancy, lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sore throat; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score immediately after extubation, 2h, 6h, 12h, 24h, 48h postoperative sore throat;Incidence and grade of cough during extubation;Incidence of postoperative nausea and vomiting;Incidence of postoperative dysphagia;Incidence of hoarseness immediately after extubation, 2h, 6h, 12h, 24h, 48h after surgery;Preoperative albumin levels;Serum magnesium ion concentration before operation;Postoperative serum magnesium ion concentration;Intraoperative remifentanil consumption;Intraoperative atropine dosage;Intraoperative infusion volume;Hemodynamic indexes 5min after intubation and every 30min during operation;Intraoperative urine volume;Intraoperative airway pressure;Tracheal catheter cuff pressure;The 15-item Quality of Recovery Score Scale (QoR-15) score 48h after surgery;Remedial analgesics within 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactGuanglei Wang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed