HIV
Conditions
Interventions
Treatment group:Contizolamide
Sponsors
Department of Pharmacy, Beijing You'an Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Men or women aged =18 years; (2) HIV-infected individuals who meet the diagnostic criteria for HIV infection and have a CD4 cell count <200/µL; (3) Those with confirmed or proposed diagnosis of concomitant Gram-positive bacterial infection in combination with clinical and laboratory evidence; (4) Subjects (or their legal representatives/guardians) who understand the steps and content of the study, sign an informed consent form, and are willing to participate in this study.
Exclusion criteria
Exclusion criteria: (1) Those who are allergic to oxazolidinones or have severe allergies (e.g., atopic dermatitis, bronchial asthma); (2) Those who are unable to administer the drug or unsuitable for administration via nasal/gastrointestinal nutritional tubes, etc., or those who have gastrointestinal disorders that would severely interfere with the absorption of orally administered drugs; (3) Those with an expected survival time of <6 months; (4) Those with body temperature =40°C; hemodynamic instability or altered mental status; (5) CrCl 30 mL/min or oliguria <20 mL/h unresponsive to rehydration, or any form of dialysis; (6) Those with abnormal QTC intervals (QTc =500 msec); (7) Clinical studies with other drugs or medical devices within 3 months prior to enrollment; (8) Those who, in the opinion of the investigator, are unsuitable for participation in this clinical study for a variety of reasons or who have an impact on the assessment of endpoints.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood concentration of contezolid; | — |
Countries
China
Contacts
Public ContactWei Liu
Department of Pharmacy, Beijing You'an Hospital
Outcome results
None listed