Gastrointestinal tumors
Conditions
Interventions
the group of esketamine:From skin incision to abdominal closure, esketamine was continuously infused at a rate of 0.1 mg·kg?1·h?1, with the remainder of general anesthesia maintained according to rou
The normal saline group.:From skin incision to abdominal closure, an equal volume of normal saline was administered, with the remainder of general anesthesia maintained according to routine protocols.
Sponsors
The Second Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 65 and 80 years old, gender not limited. 2. American Society of Anesthesiologists (ASA) physical status classification I to III. 3. Body Mass Index (BMI) between 18 to 30 kg/m^2. 4. Scheduled to undergo elective laparoscopic gastrointestinal surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to participate in the study. 2.Long-term use of analgesic drugs or psychotropic medications, with contraindications to or addiction to opioids and esketamine. 3.History of severe renal or hepatic dysfunction, or delayed recovery from general anesthesia. 4.Preoperative Pittsburgh Sleep Quality Index (PSQI) score higher than 7. 5.History of schizophrenia, epilepsy, or neurodegenerative diseases (Alzheimer's disease and Parkinson's disease). 6.Preoperative delirium or communication disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of sleep disturbance on postoperative day 1 (POD 1). Subgroup analysis was performed according to patient age (65–70 years, 71–75 years, and 76–80 years) to explore the differential effects of the intervention on the incidence of sleep disturbance on POD 1 across the three age groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of sleep disturbance on postoperative days 2–3 (POD 2–3).;postoperative sleep quality;postoperative anxiety and depression;intraoperative opioid consumption (sufentanil and remifentanil);postoperative pain score;the number of effective bolus demands via postoperative patient-controlled intravenous analgesia (PCIA);the incidence of postoperative adverse reactions (nausea and vomiting, dizziness, hallucination, and respiratory depression);plasma biomarkers; | — |
Countries
China
Contacts
Public ContactHe Xingying
The Second Affiliated Hospital of Naval Medical University
Outcome results
None listed