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Influence of flap surgery on blood supply and osteogenesis in the area of guided bone regeneration

Influence of flap surgery on blood supply and osteogenesis in the area of guided bone regeneration

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087211
Enrollment
Unknown
Registered
2024-07-23
Start date
2024-07-30
Completion date
Unknown
Last updated
2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dentition defect

Interventions

A1:Trapezoidal flap
A2:Rectangular flap
B1:proximo-central vertical incision angle-shaped flap
B2:distal-central vertical incision angle-shaped flap
C1:Sharp separation of periosteum
C2 :Blunt separation of periosteum

Sponsors

The Second Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. absence of any systemic disease that may impair implant wound healing; 2. recruitment to the study was limited to subjects aged = 18 years with a standardized health questionnaire score of 1 or 2; 3. appropriate periodontal health (only patients with PD < 5 mm; probing bleeding score and whole mouth plaque score < 20% were included to minimize the occurrence of biological complications after the procedure); 4. missing maxillary anterior teeth and presence of adjacent natural teeth; 5. other conditions related to post-extraction implant parameters include. a Presence of more than 4 mm of apical bone for initial stabilization; b Loss of buccal bone plate not exceeding 3 mm and horizontal bone gain not greater than 3 mm; c The absence of chronic periapical lesions that predispose to significant bone loss; d Presence of 2 mm of keratinized gingiva; 6. Voluntary participation and signing of the appropriate informed consent form; 7. Good patient compliance and ability to review as required.

Exclusion criteria

Exclusion criteria: 1. medically compromised subjects (ASA Class III-V) (American Society of Anesthesiologists surgical risk classification of patients); 2. general contraindications to implant therapy or adjuvant surgery (e.g., immunodeficiency, advanced systemic disease, corticosteroid medication); 3. Bone defects due to invasive, malignant bone tumors and treatments or diseases that may affect bone conversion or metabolism of bone or non-mineralized tissue (e.g., bisphosphonates or local radiation therapy); 4. Patients who are not eligible for GBR surgery or dental implant placement; 5. Heavy smokers (more than 10 cigarettes per day) during the same period; 6. Participation in other clinical trials within 3 months prior to the start of the study; 7. patients with severe cardiac, hepatic, or renal insufficiency (cardiac function = Class II, glutamic acid aminotransferase AST greater than twice the upper limit of normal, serum creatinine greater than the upper limit of normal); patients with diabetes mellitus that is poorly controlled (fasting blood glucose = 8.0 mmol/L even after medication control); 8. Mental anomalies, no behavioral autonomy; allergic patients, pregnant women or breastfeeding and those who plan to become pregnant within six months; 9. Patients who can not follow the requirements of follow-up lost visits.

Design outcomes

Primary

MeasureTime frame
Mean blood flow velocity;Maximum blood flow velocity;

Secondary

MeasureTime frame
S/D;pulsatility index;resistance index;

Countries

China

Contacts

Public ContactRong Xia

The Second Affiliated Hospital of Anhui Medical University

xiarongqh@aliyun.com+86 153 0560 9415

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026