Helicobacter pylori infection
Conditions
Interventions
Group A:Vonoprazan 20mg twice a day and amoxicillin 1.0g three times a day for 14 days
Group B:Vonoprazan 20mg twice a day and amoxicillin 1.0g three times a day for 10 days
Group C:Vonoprazan 20mg twice a day, amoxicillin 1.0g twice a day and colloidal bismuth pectin 220mg twice a day for 14 days
Group D:Esomeprazole 20mg twice a day, amoxicillin 1.0g twice a day, clarithromycin 0.5g twice a day, colloidal bismuth pectin 220mg twice a day for 14 days
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients who were diagnosed as H. pylori infection by positive13C-urea breath test, serum antibody test or gastroscopy histology examination, and in need to eradicate H. pylori; 2.Adult patients aged between 18 and70 years willing to participate; 3.Informed and agreed to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Use of proton pump inhibitor, bismuth, antibiotics one month before initiating treatment; 2. Previous H. pylori infection treatment history; 3. Previous surgical history of upper gastrointestinal diseases; 4. Pregnant and breastfeeding patients; 5. Presence of severe diseases, such as mental illness, respiratory, heart, liver or kidney diseases, malignant tumors, and other diseases before entering hospital; 6. Alcohol abuse, or other conditions which increase the risk of adverse reaction; 7. Patients are less adherent; 8. Allergy to related medications, or with severe adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reaction;adherence; | — |
Countries
China
Contacts
Public ContactSongze Ding
Henan Provincial People’s Hospital
Outcome results
None listed