Liver disease
Conditions
Interventions
Group P:goal-directed crystalloid solution
Group P:goal-directed colloid solution
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meet the indications of laparoscopic liver resection ; 2.Aged 18-65 years old ; 3.ASA grade I-III ; 4.Child-pugh grade A or B;
Exclusion criteria
Exclusion criteria: 1.known allergy to HES; 2.coagulation disorders (activated partial thromboplastin time greater than 1.5 times normal value); 3.preoperative renal insufficiency (serum creatinine greater than 2 mg/dl, oliguria, anuria, or hemodialysis); 4.cardiac arrhythmias; 5.estimated ejection fraction <35%; 6.severe chronic obstructive pulmonary disease (Stage 4); 7.Patients who received liver surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 recovery quality scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain quality score;First exhaust time;Nausea and vomiting score;intraoperative blood loss;Main complications 30 days after operation;Secondary complications 30 days after operation;Occurrence of acute kidney injury;The time of getting out of bed and hospitalization;Total bilirubin;direct bilirubin;Glutamic pyruvic transaminase;glutamic-oxalacetic transaminase;Creatinine;Blood urea nitrogen;Occurrence frequency and duration of hypotension;Lactic acid;Glucose;Central venous oxygen saturation;Intraoperative hemodynamics;The use of vasoactive drugs;Surgery and anesthesia time, time of clamping porta hepatis, awakening time, extubation time, PACU stay time;SVV, SVI, CI, CVP;The amount of crystal and colloid used during operation; | — |
Countries
China
Contacts
Public ContactDunyi Qi
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed