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The clinical significance and mechanism of neutrophil extracellular traps in atrial fibrillation

The clinical significance and mechanism of neutrophil extracellular traps in atrial fibrillation

Status
Recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400087177
Enrollment
Unknown
Registered
2024-07-22
Start date
2023-08-28
Completion date
Unknown
Last updated
2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation

Interventions

Sponsors

Changzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with atrial fibrillation :(1) aged 18-80 years; (2) Patients have certain language expression and understanding ability, understand and voluntarily fill in the informed consent form, cooperate with the completion of blood testing, stool collection and scale filling (PHQ-9); (3) Previous electrocardiogram or holter electrocardiogram or portable electrocardiograph indicated atrial fibrillation; (4) Patients with paroxysmal and persistent atrial fibrillation were included. Type definition of atrial fibrillation: paroxysmal atrial fibrillation refers to spontaneous termination within 7 days of onset or intervention termination of atrial fibrillation, persistent atrial fibrillation refers to a duration of more than 7 days of atrial fibrillation, including > Prolonged atrial fibrillation refers to a type of atrial fibrillation that has lasted for more than 12 months when rhythm control strategies are decided upon. Permanent atrial fibrillation refers to a type of atrial fibrillation in which the doctor and the patient jointly decide not to restore or maintain sinus rhythm, reflecting the attitude of the patient and the doctor towards the treatment of atrial fibrillation, rather than the pathophysiological characteristics of atrial fibrillation itself. If rhythm control is reconsidered, long-term persistent atrial fibrillation is treated. Healthy Group: (1) Age 18-80 years old, gender unlimited; (2) Patients have certain language expression and understanding ability, understand and voluntarily fill in the informed consent form, cooperate with the completion of blood testing, stool collection and scale filling (PHQ-9); (3) There was no history of atrial fibrillation, and previous ECG or holter ECG showed sinus rhythm.

Exclusion criteria

Exclusion criteria: (1) Patients with a history of ablation of atrial fibrillation, valvular atrial fibrillation, severe organic heart disease, acute phase of infection, autoimmune disease, severe hepatic and renal insufficiency, pregnancy, or mental abnormality; (2) Patients with transient atrial fibrillation secondary to reversible causes: hyperthyroidism, acute pulmonary embolism, recent surgery, acute myocardial infarction, etc.; (3) patients with advanced malignant tumors, liver fibrosis or pulmonary fibrosis and other serious complications; (4) Patients with a previous history of cardiac surgery or other surgical operations in the past 3 months.

Design outcomes

Primary

MeasureTime frame
Neutrophil Extracellular Traps;

Secondary

MeasureTime frame
left atrial diameter;

Countries

China

Contacts

Public ContactChenghao Zhong

Changzhou First People's Hospital (The Third Affiliated Hospital of Soochow University)

931834080@qq.com+86 138 0907 1264

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026