ischemic stroke
Conditions
Interventions
combining treatment group:After randomization, mechanical thrombectomy are performed to open blood flow, balloon plasty, stenting and other remedial treatments are still included in the study. After
Endovascular interventional therapy alone group:Blood flow opening (mechanical thrombectomy, thrombus extraction, balloon forming, stent placement, etc.)is performed routinely, without cold saline per
Sponsors
Hubei No.3 People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age over 18 years; 2) The time from onset to randomization is within 24h; 3) Acute ischemic stroke was clinically diagnosed; 4) mRS 0-1 score before the stroke; 5) NIHSS score >=6 before randomization; 6) CT ASPECTS score >=3 before randomization; 7)CTA/MRA/DSA confirmed acute occlusion in the following parts: intracranial segment of internal carotid artery, M1 segment of middle cerebral artery, and main segment of M2 segment of middle cerebral artery; 8) Consent to endovascular therapy; 9) Written informed consent signed by the patient or his legal representative.
Exclusion criteria
Exclusion criteria: 1)CT or MRI suggest intracranial hemorrhage. 2) Pregnant or lactating women; 3) Severe allergy to contrast media; 4) Systolic blood pressure > 220mm Hg or diastolic blood pressure > 110mm Hg, and cannot be controlled by antihypertensive drugs; 5) Genetics or acquired bleeding constitution, lack of anticoagulation factors; Or have taken oral anticoagulants and INR> 3.0; 6) Blood glucose 22.2mmol/L(400mg/dl); 7) Severe renal insufficiency (glomerular filtration rate 220umol/L(2.5mg/dl)); 8) History of bleeding (gastrointestinal and urinary tract bleeding) in the past 1 month; 9) Severe infection; 10) Intracranial aneurysm, arteriovenous malformation; 11) Brain tumors with space occupying effect on imaging; 12) Life expectancy < Six months; 13) Participating in other clinical trials; 14) The follow-up is not expected to be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of 0–2 on the modified Rankin Scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| mRS score at 90 days; | — |
Countries
China
Contacts
Public ContactYue Wan
Hubei No.3 People's Hospital of Jianghan University
Outcome results
None listed