Parkinson's disease
Conditions
Interventions
Experimental group(Stage1):Repetitive transcranial magnetic stimulation
Experimental group(Stage2):Repetitive transcranial magnetic stimulation
Control group(Stage2):False stimulation
Sponsors
The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria of the Parkinson's Disease Society Brain Bank in the UK; 2. Meets the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV); 3. If the subject is taking oral PD medication, they must have a stable PD medication regimen for at least 28 days and maintain the regimen unchanged during treatment and follow-up; 4. Being able to sign informed consent forms for research.
Exclusion criteria
Exclusion criteria: 1. Secondary Parkinson's syndrome or Parkinson's syndrome accompanied by multiple system atrophy, progressive supranuclear palsy, and other diseases; 2. Merge serious cardiovascular, respiratory, digestive and other diseases; 3. Implant any cardiac pacemaker, deep brain stimulator, or other TMS therapy contraindications; 4. Accompanied by dementia or severe mental symptoms; 5. Have received any antidepressant treatment within 2 months prior to screening; 6. Those who are unable to cooperate in completing clinical scale assessments, imaging examinations, or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-24 efficacy and response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-24 score reduction rate;HAMA score reduction rate; | — |
Countries
China
Contacts
Public ContactWeiguo Liu
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University
Outcome results
None listed