Depression
Conditions
Interventions
Experimental group:Take FMT capsules
Control group:Take Sertraline
Sponsors
The First Affiliated Hospital of Xi 'an Jiaotong University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: ?12 years old =18 years old; ? In line with the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-V) "major depressive disorder" diagnostic criteria; ? The first episode, 12 points = Montgomery Depression Scale (MADRS) score =30 points; ? This episode has not been treated with effective antidepressant therapy (antidepressant drugs have not reached the effective dose or reached the effective dose but the course of treatment is less than 2 weeks); ? Right-handed; ? Primary school education and above; ? I and my guardian know and agree to participate in this project.
Exclusion criteria
Exclusion criteria: ? Use antibiotics within 1 month or there is an active infection; ? The female is pregnant or lactating; ? Suffering from serious unstable cardiovascular disease, liver disease, kidney disease, etc.; ? Suffering from malignant tumor disease or serious systemic disease; ? Suffering from other mental disorders, such as bipolar disorder, compulsive disorder; ? Accompanied by intestinal diseases that severely damage the intestinal barrier, such as inflammatory bowel disease; Previous suicidal behavior or family history of suicide, or current MADRS 10 > 2 points; ? Poor treatment compliance; ? Any other conditions that the investigator deems unsuitable for inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery depression scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton anxiety scale;9 items Patient health questionnaire;Clinical Global Impression; | — |
Countries
China
Contacts
Public ContactMa Xiancang, Zhu Feng
The First Affiliated Hospital of Xi 'an Jiaotong University
Outcome results
None listed