Overweight/Obesity
Conditions
Interventions
Carbohydrate-cycling group:Carbohydrate-cycling diet
Isocaloric carbohydrate non-cycling control group:Isocaloric carbohydrate non-cycling diet
Sponsors
Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1)Provided informed consent and voluntarily agree to participate in the study; (2)Age between 18 and 60 years; (3)BMI between 24 and 40 kg/m²; (4)Residing in Shanghai for the duration of the study.
Exclusion criteria
Exclusion criteria: (1)Diagnosis of type 1 or type 2 diabetes; (2)History of cardiovascular events (e.g. angina, myocardial infarction, stroke) within 6 months prior to enrollment; (3)Current use of anti-obesity medications; presence of eating disorders or active dieting behaviors; weight loss>5 kg within the past 6 months; (4)Chronic kidney disease with an estimated glomerular filtration rate (eGFR < 50 mL/min/1.73 m²); (5)Any condition associated with fluid overload, such as heart failure or cirrhosis; (6)Diagnosed psychiatric disorders (e.g., schizophrenia, post-traumatic stress disorder, obsessive-compulsive disorder), uncontrolled depression, or uncontrolled epilepsy; (7)History of severe gastrointestinal disease or gastrointestinal surgery within the past 12 months; (8)Severe arthritis or active gout; (9)Medical conditions contraindicating or preventing high-intensity physical activity (e.g., foot ulcers, peripheral neuropathy); (10)Active gallstone disease or known asymptomatic gallstones; (11)Obesity caused by other endocrine disorders (e.g., Cushing’s syndrome); (12)Current or recent (within 3 months prior to screening) use of medication known to cause significant weight gain, including systemic corticosteroids (except for short-term courses of 7 to 10 days), tricyclic antidepressants, atypical antipsychotics, and mood stabilizers (e.g., imipramine, amitriptyline, mirtazapine, paroxetine, clozapine, olanzapine, valproic acid and its derivatives, lithium); (13)History of bariatric surgery (excluding liposuction performed more than 1 year prior to enrollment); (14)Concurrent participation in another clinical trial; (15)Pregnant or lactating women, or those planning to become pregnant during the study period; (16)Current diagnosis of any malignancy; (17)Failure to pass the adherence screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anthropometric and body composition indicators;Blood glucose indicators;Cardiovascular indicators;Liver and kidney function indicators;Indicators of inflammation and immune function;Subjective health indicators; | — |
Countries
China
Contacts
Public ContactWenze Zhong
Shanghai Jiao Tong University School of Medicine
Outcome results
None listed