irritable bowel syndrome with predominant diarrhea
Conditions
Interventions
IBS-D group:NA
Sponsors
the First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1)Meet the diagnostic criteria of IBS-D in Rome IV; (2) IBS-SSS is greater than 75 points; (3) Aged 18-60 years old.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) organic gastrointestinal diseases: such as peptic ulcer, inflammatory bowel disease, celiac disease, acute and chronic intestinal infection, lactose intolerance, etc.; (3) Diseases that may be related to intestinal permeability: rheumatoid arthritis, pancreatitis, liver cirrhosis, food allergy, collagenous vascular disease, kidney disease, chronic skin disease; (4) Other diseases: tumor, thyroid disease, diabetes; (5) Patients who took nonsteroidal anti-inflammatory drugs, aspirin, alcohol, or other drugs that may affect intestinal permeability and allergic reactions during the first 2 weeks of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NGF;GAP43;TrkA;NLRP3;ASC;caspase-1; | — |
Countries
China
Contacts
Public ContactHongmei Tang
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed