None listed
Conditions
Interventions
Experiment Group:dexmedetomidine (0.2 ug/kg/h) was continuously infused in the night before operation to the morning of the surgical day
Control Group:accepted saline infusion with same speed
Sponsors
Shanghai Yangpu District Shidong Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients planned for hip fracture surgery, including proximal femoral nail anti-rotation, cannulated screw fixation, hemiarthroplasty or total hip replacement; 2. Aged 65-90 years old; 3. American Society of Anesthesiologists (ASA) Physical Status classification I–III; 4. Underwent general anesthesia; 5. Voluntary participation in the trial and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of mental illness or disease in nerve system, including hearing and visual impairment, stroke, transient ischemic attack (TIA) and other brain diseases within 3 months; 2. Patients with a history of dementia or preoperative Minimum Mental State Examination (MMSE) Score <= 23 points, evaluated 1 day before surgery ; 3. Illiterate patients; 4. Patients with communication difficulties and unable to complete cognitive function tests; 5. Patients with a history of severe liver (Child-Pugh class C ) or kidney (requiring renal replacement therapy) disease; 6. Body mass index (BMI)?35 kg/m2, sleep apnea syndrome; 7. Long-term use of psychotropic drugs, or alcohol abuse; 8. Cardio-vascular malfunctions, including sinus bradycardia (heart rate<60 beats/min), sick sinus syndrome, Wolffian Parkinson-White syndrome, second-degree atrioventricular block, or a history of cardiovascular accidents; 9. Allergic to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory biomarkers; | — |
Countries
China
Contacts
Public ContactJinchao Song
Shidong Hospital of Shanghai
Outcome results
None listed