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Dexmedetomidine as an adjuvant to plain ropivacaine for labor analgesia with puncture epidural technique: a trial for EC50 determination using an up-down sequential allocation method

Dexmedetomidine as an adjuvant to plain ropivacaine for labor analgesia with puncture epidural technique: a trial for EC50 determination using an up-down sequential allocation method

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087091
Enrollment
Unknown
Registered
2024-07-19
Start date
2024-07-20
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

labor analgesia

Interventions

group 1:The dose of ropivacaine used by the first patient was 0.1%. The effective definition is a visual analogue score (VSA) = 3 within 30 minutes of epidural injection load. Determine the effective
group 2:The dose of dexmedetomidine for each patient is 0.4ug/ml, and the dose of ropivacaine used for the first patient is 0.1%. The effective definition is a visual analogue score (VSA) = 3 within 3

Sponsors

No. 50, Boyuan Avenue, Yufeng District, Liuzhou, Guangxi
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. primiparous women; 2. Healthy single pregnancy; 3. Full term pregnancy (gestational age = 37 weeks); 4. Age range from 18 to 45 years old; 5. ASA level II or III; 6. Cervical dilation during the latent period of labor is less than 5cm, and the pain score is greater than 5 points.

Exclusion criteria

Exclusion criteria: 1. Contraindications to spinal anesthesia; 2. Serious pregnancy complications (such as preeclampsia, heart failure, severe anemia, pregnancy with diabetes); 3. BMI>40 kg/m-2; 4. Bradycardia or concomitant atrioventricular block; 5. History of cesarean section surgery; 6. Known fetal abnormalities; 7. Allergy or hypersensitivity to ropivacaine or dexmedetomidine.

Design outcomes

Primary

MeasureTime frame
Whether the pain relief during childbirth is successful or not;

Secondary

MeasureTime frame
sensory block level ;Numerical Rating Score for pain ;Bromage Score;adverse events ;

Countries

China

Contacts

Public ContactHu Jing

Guangzhou Women and Children's Medical Center Liuzhou Hospital

15077202268@139.com+86 150 7720 2268

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026