Postoperative pain of breast cancer
Conditions
Interventions
Ropivacaine Group:Using Pecs II, inject 30 ml of 0.5% ropivacaine
Bupivacaine liposome Group:Using Pecs II, inject 20 ml of 1.3% bupivacaine liposome injection
Sponsors
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Female patients scheduled to undergo unilateral simple mastectomy with sentinel lymph node biopsy or modified radical mastectomy for breast cancer 2. Aged >=18 3. ASA grade 1 to 2 4.Cardiovascular function 1 to 2 5. BMI <30kg/m2
Exclusion criteria
Exclusion criteria: 1.Use of long-acting opioids, non-steroidal anti-inflammatory drugs, acetaminophen, or aspirin (except for cardioprotective low-dose aspirin) within 3 days prior to surgery or use of any opioid within 24 hours prior to surgery. 2.Patients with severe cardiac insufficiency, pulmonary dysfunction, hepatic or renal impairment, severe hypertension or diabetes mellitus. 3.Patients with a previous history of breast cancer surgery. 4.Patients with previous history of allergy to local anesthetics. 5.Patients with co-morbid systemic infectious diseases, recently treated with hormones or steroids. 6.Patients with skin lesions or infections at the nerve block site. 7.Patients with chronic pain (lasting >3 months), long-term use of analgesic and sedative medications or a history of substance abuse. 8. Patients with preoperative cognitive function or hearing impairment who are unable to cooperate with the blockade.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the resting pain score curve within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score at the first use of rescue analgesics after surgery;Overall benefit questionnaire results of postoperative pain relief scores at 24, 48, and 72 hours;subject satisfaction with postsurgical pain control at 72 h and at day 30;Incidence of adverse reactions to nerve blocks;The incidence of acute moderate to severe pain 72 hours after surgery;The incidence of chronic moderate to severe pain at 3 months after surgery;Postoperative recovery;Related inflammatory indicators; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed