Type 2 diabetic osteoporosis
Conditions
Interventions
Gold Standard:DXA test to diagnose osteoporosis: Measurement of 2 sites, lumbar spine and hip, selecting 3 regions of interest (ROIs), 1st to 4th lumbar vertebrae, femoral neck of hip and total hip, a
Index test:Advanced Glycosylation End Products of the Lens, BMI, fasting glucose, blood calcium, alkaline phosphatase, type I collagen cross-linked C-terminal peptide, osteocalcin N-terminal mid-molec
Sponsors
The First Affiliated Hospital of University of South China
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: OP group: (1) age =40 years; (2) meet the 1999 World Health Organisation (WHO) diagnostic criteria for T2DM; (3) have an informed consent process and signed an informed consent form; (4) Measured BMD levels are at least 2.5 standard deviations below the peak bone mass of young people of the same sex and race in the normal population. NOP group: (1) age =40 years; (2) meet the 1999 World Health Organisation (WHO) diagnostic criteria for T2DM; (3) have an informed consent process and sign the informed consent form; (4) Bone density levels tested were not less than 2.5 standard deviations below the peak bone value of a normal population of young people of the same sex and race..
Exclusion criteria
Exclusion criteria: (1) Patients with other types of diabetes mellitus except T2DM;(2) patients with cognitive and communication dysfunction; (3) patients with severe cardiac, pulmonary, hepatic, renal insufficiency or other serious diseases;(4) patients with prolonged bed rest and lack of exercise; (5) patients with other bone metabolism anomalies such as rickets, osteomalacia, osteosclerosis, etc.; (6) patients with long term use of medications affecting bone metabolism, such as hormones, Vitamin D, and calcitonin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Advanced Glycosylation End Products of the Lens; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical index;Body mass index; | — |
Countries
China
Contacts
Public ContactLiyan Jiang
The First Affiliated Hospital of University of South China
Outcome results
None listed