Heart disease
Conditions
Interventions
Control group (Group C):0.9% sodium chloride injection intravenous micropump
Dexmedetomidine Group (Group D):10 minutes before anesthesia induction, a micropump was used to pump continuously at a rate of 0.4 µg·kg-1·h-1 until the end of the operation
Shenmai injection group (S group):After 10 minutes of successful anesthesia-induced intubation and at the beginning of the transfer, 0.6 mL/kg Shenmai injection (Dali Pharmaceutical Co., Ltd., 10ml/tu
Dexmedetomidine + Shenmai injection group (DS group):10 minutes before anesthesia induction, a micropump pump was used to pump continuously at a rate of 0.4 µg·kg-1·h-1 until the end of the operation.
Sponsors
Guangxi Zhuang Autonomous Region People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: Inclusion criteria: (1) informed consent of patients and families; (2) Age> 60 years old; (3) ASA is graded at Class II or III; (4) NYHA is graded as Class II or III; (5) For cardiac patients who undergo elective cardiovascular surgery, the left ventricular ejection fraction EF=45%; (6) No myocardial infarction in the past 3 months; (7) There was no severe heart failure and malignant arrhythmia in the past, and no hyperglycemia and hypertension that were difficult to control; (8) No severe hearing and visual impairment.
Exclusion criteria
Exclusion criteria: 1: Exclusion criteria: (1) preoperative cognitive impairment or mental illness and inability to communicate; (2) Those who have adverse reactions to ginseng injection; (3) Those with severe liver, kidney, lung and brain dysfunction before surgery; (4) the presence of sinus bradycardia and atrioventricular block of any level before surgery; (5) There was an allergic phenomenon to the relevant anesthetic drugs and experimental drugs involved in this study, as well as a history of severe plasma allergy; (6) Those who have recently used traditional Chinese medicine treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WBC;N%;HMGB1;hs-CRP;CK-MB;cTnI;NSE;S100ß;MMSE;CAM;SCL-90; | — |
Countries
China
Contacts
Public ContactGongZheng
Guangxi Zhuang Autonomous Region People's Hospital
Outcome results
None listed