idiopathic podocytopathies
Conditions
Interventions
Control group:Valsartan capsule, 80mg once daily for 48 weeks
Daglizin tablet, 10mg once daily for 48 weeks.
Experimental group:Valsartan capsule, 80mg once daily for 48 weeks
Daglizin tablet, 10mg once daily for 48 weeks
Yuebi Decoction and Fangji Huangqi decoction, twice a day, one pack each time, a total of 48 weeks.
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The pathologic types of renal puncture and biopsy are primary minimal change disease (MCD), primary focal segmental glomerulosclerosis (FSGS) and primary membranous nephropathy (MN). 2. The clinical manifestation is proteinuria, which may be combined with hematuria, edema, hypertension and renal insufficiency. 3. When enrolled, the glomerular filtration rate was >30ml/min·1.73m2 (calculated according to EPI formula). 4. 24-hour urinary protein quantity =1.0g and <3.5g at the time of enrollment. 5. Age =18 years old and =70 years old, regardless of gender. 6. Patients who have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with chronic kidney disease stage 4, stage 5 and kidney replacement therapy. 2. Patients with contraindications to valsartan capsules or daglipzin tablets, including renal artery stenosis, hyperkalemia, isolated kidney, urinary tract infection, etc. 3. Patients with severe infection, malnutrition, and acute renal failure. 4. Serious damage to heart, liver or brain function or other serious underlying diseases. 5. People who are known to be allergic to the Chinese medicine ingredients used. 6. Pregnant or lactating women. 7. People with severe mental illness. 8. Have participated in or are undergoing other clinical trials within 1 month before enrollment.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Blood lipid;TCM syndrome score;Urine podocyte damage marker protein; | — |
Primary
| Measure | Time frame |
|---|---|
| Routine urine test;24-hour urinary protein quantity;Serum albumin;Renal function;Glomerular filtration rate; | — |
Countries
China
Contacts
Public ContactTianwen Yao
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed