Coronary Heart Disease
Conditions
Interventions
Remimazolam combined with esketamine group (group RE):General anesthesia induction with remimazolam 0.2~0.3mg/kg and esketamine 0.3mg/kg
Propofol group(group P):General anesthesia induction with propofol 1.5~2.5mg/kg
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Conform to the international standards for clinical diagnosis and naming of ischemic heart disease; (2) Gender is not limited, age 18~75 years old, ASA grade II~III, NYHA grade I~II, BMI 18~30kg/m2; (3) Patients who are scheduled to undergo laparoscopic surgery (gastrointestinal/pancreatic/bile duct/liver malignancy) under general anesthesia; (4) Subjects voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those who have contraindications to general anesthesia or are allergic to or contraindicated to the study drug; (2) Combined with valvular heart disease or atrial fibrillation; (3) poorly controlled or untreated hypertension; (4) Obvious abnormality of liver and kidney function; (5) Poorly controlled diabetes mellitus (fasting blood glucose > 11.1mmol/L); (6) Psychiatric or neurological disorders and a history of drug and/or alcohol abuse; (7) Pregnant or lactating women; (8) Those who are unable to obtain cardiac ultrasound images or whose image quality is poor and cannot be analyzed; (9) Unable to cooperate or refuse to participate in the participant; (10) Other conditions judged by the investigator to be unsuitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke volume(SV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular outflow tract velocity-time integral(LVOT-VTI);Cardiac output;Intraoperative analgesic drug dosage;Analgesic drug consumption 24 hours postoperatively;15-item recovery quality scores(QoR15);Athens Insomnia Scale score(AIS);Hamilton Anxiety Scale score(HAMA);The incidence of adverse reaction within 24 hours after surgery;Visual Analogue Scale Score; | — |
Countries
China
Contacts
Public ContactJin Yanwu
The Second Hospital of Shandong University
Outcome results
None listed