Pulmonary disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1)Age =18 years old 2)ASA: I-III 3)Selective thoracoscopic surgery requiring OLV under general anesthesia (excluding emergency surgery) 4) Sign informed consent
Exclusion criteria
Exclusion criteria: 1) For any reason, it is impossible to cooperate with the study or the researcher thinks that it is not suitable to be included in this experiment. 2) Preoperative history of lung surgery or uncontrollable asthma. 3) Adverse events listed as pulmonary complications before anesthesia induction (aspiration, moderate respiratory failure, pulmonary exudation, pulmonary infection, atelectasis, cardiogenic pulmonary edema, pleural effusion, pneumothorax, pulmonary embolism, purulent pleurisy and pulmonary hemorrhage). 4) COPD III and IV (GOLD grade), pulmonary fibrosis, pulmonary bullae, severe emphysema or pneumothorax. 5) Patients with cardiac insufficiency (NYHA cardiac function grade =3), previous history of cerebral infarction (previous hospitalization and treatment), intracranial hypertension, severe liver disease (such as liver cirrhosis with Child-Pugh score of B or C) or chronic renal failure (glomerular filtration rate < 30 ml/min). 6) Have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of atelectasis 30 minutes after tracheal extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung ultrasound score 30 minutes after extubation;Maximum peak airway pressure during lung recruitment;Incidence of hypoxic events (SpO2?92%) in postoperative PACU; | — |
Countries
China
Contacts
West China Hospital of Sichuan University