acute abdomen
Conditions
Interventions
Experimental group:Using norepinephrine as a vasoactive drug to regulate blood pressure
Control group:Using phenylephrine as a vasoactive drug to regulate blood pressure
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Age over 18 years (2) General surgery patients diagnosed with acute abdomen and planning to undergo emergency surgery (3) The anesthesia is general anesthesia
Exclusion criteria
Exclusion criteria: (1) ACEI / ARB, mineralocorticoid receptor blockers, renin inhibitors and other drugs were taken before operation. (2) hyperthyroidism / hypothyroidism, taking contraceptives or during pregnancy, and testosterone or cortisol disorders (3) Severe sinus bradycardia ( HR < 50 beats / min ). (4) Atrioventricular block grade II or above and no pacemaker (5) Congenital heart disease or other severe cardiovascular diseases above NYHA class III. (6) Severe liver dysfunction ( Child-Pugh C ) (7) Chronic kidney disease ( GFR < 60ml / min / 1.73m2 or end-stage renal disease requiring renal replacement therapy ). (8) Refusing to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| renin;Ang?;aldosterone;ACE2 activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury;Incidence of myocardial injury after non-cardiac surgery;adverse cardio-renal events;Postoperative ICU admission ( planned, unplanned, admission time );Length of hospital stay;30-day mortality;rehospitalization within 30 days after surgery;other adverse outcomes;Serum creatinine;cTn;Incidence of severe acute kidney injury;Quality of recovery; | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed