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The impact of opioid analgesia strategy on postoperative delirium and recovery quality in elderly patients undergoing joint replacement surgery

The impact of opioid analgesia strategy on postoperative delirium and recovery quality in elderly patients undergoing joint replacement surgery

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087014
Enrollment
Unknown
Registered
2024-07-17
Start date
2024-07-18
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee or hip disease

Interventions

Continuous nerve block group:Postoperative PCNA was performed, with patients undergoing hip arthroplasty receiving continuous iliac fascia plane block and patients undergoing knee
Single LB nerve block group:Postoperative single nerve block was performed, with hip replacement patients receiving iliac fascia plane block and knee replacement patients receivi
Intravenous analgesia group:PCIA was performed postoperatively, and the drug formula was sufentanil 250ug + dexmedetomib 200ug plus normal saline diluted to 250ml, loading dose: 0.05µg/kg
Background dose: 0.04 µg/(kg?h)
Single shock dose: 0.01µg/kg
The locking time is 15min. Both PCNA and PCIA last three days

Sponsors

Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1: Age = 60 years old, regardless of gender 2: ASAI - Level III 3: Patients undergoing elective tracheal intubation and general anesthesia for knee or hip replacement surgery 4: BMI 18-40kg/m2 5: Sign an informed consent form and voluntarily participate in this study

Exclusion criteria

Exclusion criteria: 1: Individuals who are allergic to local anesthetic drugs 2: Infected individuals at the puncture site 3: Diseases of important organ systems 4: Those with preoperative CAM evaluation = 20 points 5: Abuse or long-term use of anesthetic, sedative, and analgesic drugs 6: Researchers believe that subjects with any other unfavorable factors to participate in this trial

Design outcomes

Primary

MeasureTime frame
confusion assessment method, CAM scale scores;Quality of Requirements-15 (QoR-15) scores at 24h, 48h and 72h after surgery;VAS scores at rest and passive exercise at 6h, 12h, 24h, 48h and 72h after surgery;Basic information;

Secondary

MeasureTime frame
The number of postoperative remedial analgesia;The first time to get out of bed after surgery;Length of stay;Nerve block related adverse events;Postoperative complication;

Countries

China

Contacts

Public ContactXian Haiyan

Second Affiliated Hospital of Guangxi Medical University

56595274@qq.com+86 135 1781 1120

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026