Effects of anesthetics on brain function
Conditions
Interventions
Propofol anesthesia group:A resting fMRI scan was performed before propofol anesthesia. Propofol was administered and physiological indicators were continuously monitored to ensure light/moderate seda
Dexmedetomidine anesthesia group:Give the right supporting pyrimidine resting state fmri scans were taken before the anesthesia. Dexmedetomidine administration was started, and the physiological param
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) health status I; (2) age =18 years old, =40 years old; (3) Native speakers of Chinese; (4) being right-handed; (5) 12 years of education or above; (6) body mass index (BMI) =30; (7) Understand the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) nervous system or cardiopulmonary diseases; (2) snoring; (3) obstructive sleep apnea syndrome; (4) claustrophobia and other contraindications to MRI scanning; (5) hearing loss; (6) history of allergy; (7) those with language disorders; (8) with cognitive impairment; (9) metallic implants in the body; (10) using anesthetics within 6 months; (11) having a history of drug abuse or alcohol abuse; (12) pregnant or lactating women; (13) The investigator considered it inappropriate to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain functional status; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function; | — |
Countries
China
Contacts
Public ContactXiaodan Wu
Fujian Provincial Hospital
Outcome results
None listed