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To investigate the analgesic effect of a single epidural injection of esmketamine in patients undergoing Enscopic lung and upper abdominal surgery: a prospective randomized controlled three-blind study

To investigate the analgesic effect of a single epidural injection of esmketamine in patients undergoing Enscopic lung and upper abdominal surgery: a prospective randomized controlled three-blind study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087004
Enrollment
Unknown
Registered
2024-07-17
Start date
2024-07-19
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain

Interventions

test group:A single epidural injection of 15mg of ketamine
control group:A single epidural injection of 0.5mg of hydromorphone

Sponsors

Zhongshan Hospital(Xiamen), Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Age> =18 years, <=80 years, gender is unlimited ? Patients undergoing elective TV-based endoscopic pulmonary and upper abdominal surgery ? ASA (American Association of Anesthesiologists classification) grades I-III

Exclusion criteria

Exclusion criteria: ? Patients who have undergone previous endoscopic or open chest and abdominal surgery; ? Patients with serious dysfunction of important organs; ? Patients with contraindications of epidural anesthesia or those unwilling to undergo epidural anesthesia; ? Patients who cannot cooperate with postoperative follow-up and communication disorders; ? Patients with a preoperative history of chronic pain or long-term use of analgesic drugs; ? Patients without adequate medical history ? Patients who refused to participate in this experiment

Design outcomes

Primary

MeasureTime frame
Intravenous hydromorphone dosage within 48h after the procedure;

Secondary

MeasureTime frame
Intraoperative hypotension;Postoperative hypotension;Time to the first use of the analgesic pump;Postoperative nausea and vomiting;

Countries

China

Contacts

Public ContactLiang Chao

Zhongshan Hospital(Xiamen), Fudan University

superwn226@126.com+86 159 2167 9955

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026