The ED95 of sufentanil inhibiting cardiovascular responses to tracheal intubation with airway topical lignocaine spray in the elderly: A biased coin Up-and-Down sequential allocation method

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400086992

Enrollment

Unknown

Registered

2024-07-16

Start date

2024-07-19

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheal intubation stimulation

Interventions

Group A:the oropharynx and airway spraying lidocaine

Group B:Saline solution

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients aged 65-80 years undergoing surgery requiring tracheal intubation ASA grade I to III

Exclusion criteria

Exclusion criteria: 1) hypertention, and basal BP > 180 mmHg; 2), difficult airway; 3) obesity (BMI>30kg/m2); 4) ischemic heart disease; 5) local anesthetic allergy; 6) diabetes associated with autonomic nerve disorder, 7) Airway hyperresponsiveness

Design outcomes

Primary

Measure	Time frame
the MAPmax or the HRmax Within 3 minutes after intubation;	—

Secondary

Measure	Time frame
Heart rate;Systolic blood pressure, SBP;Diastolic blood pressure;	—

Countries

China

Contacts

Public Contactchenxu

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine,University of Science and Technology of China

vanesth@163.com+86 183 2610 8020

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026