orthopedic trauma surgery
Conditions
Interventions
BZ Group:Application of liposomal bupivacaine for preoperative nerve blocks
R Group:Application of bupivacaine for preoperative nerve blocks
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Orthopaedic trauma surgery patients, to be performed under a single nerve block combined with general anesthesia for internal fixation of fracture osteotomy and reduction; ? Age 18-65 years old; ? ASA class I-II, normal sensory and motor function before surgery; ? Signed informed consent.
Exclusion criteria
Exclusion criteria: ? Refusing to sign the informed consent; ? preoperative combined peripheral nerve injury or lesions, combined diabetic peripheral neuropathy, rheumatoid arthritis or coagulation disorders; ? Long-term oral painkillers for chronic pain or history of drug abuse; ? Severe compound trauma; ? Pregnant women; ? History of allergy to local anesthesia drugs; ? Combined severe cardiac, hepatic and renal insufficiency; ? Presence of uncontrolled psychiatric or neurological disorders, communication disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative rebound pain in 48h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of night sleep on the night of surgery and on the first postoperative day;Pain scores and analgesic management;Incidence of postoperative nerve injury;Changes in perioperative laboratory and inflammatory indicators;Extubation time for general anesthesia patients;Postoperative sedation and awakening Situation;Time to first postoperative bedtime;Post-operative hospitalization;Incidence of perioperative complications;3-month postoperative readmission rate;Incidence of postoperative chronic pain; | — |
Countries
China
Contacts
Public ContactZhang Xiaoguang
Zhongshan Hospital, Fudan University
Outcome results
None listed