Bipolar II Disorder
Conditions
Interventions
Drug-Naive First-Episode Bipolar Disorder (BD) Patients Group:None
Health Control Group:None
Sponsors
The Third Xinagya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
13 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age 13-45 years;2. Han Chinese, right-handed;3. Sufficient comprehension ability, education level = 4 years;4. Signed informed consent. Criteria for Inclusion of Drug-Naive First-Episode Bipolar Disorder (BD) Patients: 1. Meets DSM-5 criteria for Bipolar II Disorder;2. First episode, illness duration = 18 months;3. Currently in a depressive episode, with HAMD-24 score = 20;4. Never taken antidepressants or mood stabilizers.
Exclusion criteria
Exclusion criteria: 1. Severe physical illness, pregnancy, undergoing electroconvulsive therapy, or other MRI contraindications; 2. History of neurological diseases or unexplained comas; 3. Coexisting autoimmune diseases; 4. Symptoms related to inflammation (including fever, infectious diseases, or inflammatory conditions); 5. Coexisting other psychiatric disorders and Axis II disorders such as personality disorders or intellectual disabilities; 6. Recent (within 2 weeks) use of medications affecting mood or the immune system, such as corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and statins; 7. Coagulation disorders or vascular diseases, or taking anticoagulant medications; 8. History of substance abuse; 9. Alcohol consumption or benzodiazepine use within 1 week prior to the test; 10. Participation in a PET scan within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TSPO VT;Hamilton Depression Scale, HAMD;Self-Rating Depression Scale,SDS;HCL-32;Bech-Rafaelsdn Mania Rating Scale,BRMS;TSPO Polymorphism Genotyping;Cytokine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA;Self-Rating Anxiety Scale,SAS;Scale for Assessment of Positive Symptoms,SAPS;Scale for Assessment of Negtive Symptoms,SANS;Brief Psychiatric Rating Scale,BPRS;Childhood trauma questionnaire, CTQ;Family Environment Scale-Chinese Version,FES-CV;Rosenberg self-esteem scale, SES;Chinese Perceived Stress Scales,CPSS;Simplified Coping Style Questionnaire, SCSQ;Trail Making Test;Digital-Symbol Test; | — |
Countries
China
Contacts
Public ContactWeidan Pu
The Third Xinagya Hospital of Central South University
Outcome results
None listed