lumbar disc herniation
Conditions
Interventions
Group A esketamine group:Preoperative loading dose: 0.2mg/Kg, intraoperative maintenance dose: 0.3mg/Kg/h
Group B control group:Equal amount of physiological saline solution
Sponsors
Ethics Committee of The General Hospital of Western Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Lumbar disc herniation accompanied by obvious symptoms of nerve root compression, 2. Non surgical treatment for more than three months without significant relief 3. According to imaging examination, the location and segment of lumbar disc herniation are consistent with the symptoms 4. Single segment lumbar disc herniation 5. ASA classification level I or II; 6. Age greater than 18 years old and less than 80 years old
Exclusion criteria
Exclusion criteria: 1. Accompanied by lumbar instability or severe lumbar spinal stenosis 2. Developmental abnormalities 3. Tumors or infections 4. Patients who cannot tolerate prone position local anesthesia surgery 5. Patients with dysfunction of solid organs such as heart and lungs 6. Individuals with abnormal coagulation function 7. Allergic to medication 8. Mental abnormalities, inability to communicate and cooperate 9. Patients with uncontrolled hypertension or elevated intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale;Mean Arterial Pressure;Heart rate;Blood oxygen saturation (SpO2);Sedation score;systolic pressure;diastolic pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative VAS score of lumbar ;Postoperative VAS score of lower limbs; | — |
Countries
China
Contacts
Public ContactHaiyu Fu
The General Hospital of Western Theater Command
Outcome results
None listed