pelvic organ prolapse
Conditions
Interventions
experimental group:None
control group:None
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
Female
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Previous pelvic floor reconstruction with mesh and >1 year from the last pelvic floor reconstruction with mesh procedure; (2) Enrollment criteria for the test group: patients in the test group were required to have a clinical diagnosis of mesh exposure, with mesh exposure defined as mesh visible through the vaginal epithelium for at least 2 mm. The mesh in all subjects must be a mesh implanted from the anterior pelvic/vaginal apex. Inclusion criteria for the control group: patients in the control group did not have mesh exposure, did not meet the diagnosis of mesh exposure, patients were admitted to the hospital for other pelvic floor disorders with a proposed plan for surgical removal of all/part of the mesh, and the primary surgical indication was other pelvic floor disorders such as urinary incontinence and post hysterectomy vault prolapse. All subjects must have mesh implanted from the anterior pelvic/vaginal apex. (3) Voluntary enrollment in the study with signed informed consent; (4) Age range of 40-80 years.
Exclusion criteria
Exclusion criteria: (1) Severe medical comorbidities that preclude tolerating surgery; (2) Bowel or bladder erosion of the mesh; (3) Acute episodes of inflammation, such as fever, vaginal wall abscesses, and vaginal ulcers; (4) Patients undergoing chronic immunosuppressive therapy or suffering from autoimmune diseases; (5) The presence of malignant lesions of the vagina, cervix, or endometrium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PDGFRß; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD31;Notch3;a-SMA; | — |
Countries
China
Contacts
Public ContactXin Yang
Department of Gynaecology, Peking University People's Hospital
Outcome results
None listed