uremia
Conditions
Interventions
central dialysate delivery system:ultrapure dialysate
single-patient dialysis fluid delivery system:standard dialysate
Sponsors
Changzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: age 18 to 90 years; patients undergoing maintenance hemodialysis three times weekly for more than one months; patients with white blood cell count = 4.0 × 109/L and PLT = 100.0 × 109/L for more than one month; and a willingness to participate in the study.
Exclusion criteria
Exclusion criteria: a. chronic infections or active inflammatory diseases or acute infections, b. treatment with cytostatics, anti-inflammatory drugs or glucocorticoid (GC), c. chronic bleeding or haemolysis, major surgery in the 3 months prior to start of the study, d. patients with radiotherapy or active cancer, e. patients with severe liver impairment, active autoimmune disease, active hepatitis, syphilis or acquired immune deficiency syndrome (AIDS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in IgE;Changes in hs-CRP;Changes in IL-6;Changes in TNF-a;Changes in blood urea nitrogen;Changes in creatinine;Changes in uric acid;Changes in blood calcium;Changes in blood phosphorus;Changes in ß2-MG;Changes in a1-MG;Changes in parathyroid hormone;Changes in KT/V;Changes in serum ferritin;Changes in transferrin saturation;Changes in the degree of skin itching; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in sleep quality;The incidence of hypotension;The incidence of muscle spasms;The incidence of nausea and vomiting;The incidence of headaches, chest pain, and back pain;The incidence of dialyzer reactions;Completion rate of dialysis treatment;Dosage of erythropoietin; | — |
Countries
China
Contacts
Public ContactMin Yang
The Third Affiliated Hospital of Soochow University
Outcome results
None listed