Benign gynecological tumors, Adenomyosis, etc
Conditions
Interventions
Lidocaine group:A single injection of 1.5mg/kg before anesthesia induction, slowly administered
Then infusion of 1.5mg/kg/h until the end of the surgery, the postoperative PCIA device will contain lidocaine 36mg/kg and sufentanil 2ug/kg, diluted to 200 mL in 0.9% physiological saline. The backgr
Control group:Preoperative and intraoperative physiological saline infusion at the same speed, postoperative PCIA device with sufentanil 2ug/kg, background infusion set at 4mL/h, each PCIA press with
Sponsors
Peking University of Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
33 Years to 54 Years
Inclusion criteria
Inclusion criteria: 1.33-54 year old ASAI-III grade female patients; 2. Choose a suitable time for gynecological benign disease lower abdominal open surgery (transabdominal hysterectomy, myomectomy, salpingo oophorectomy, cystectomy, or adenomyomectomy, etc.); 3. No recent respiratory infections or severe allergic reactions; 4. The estimated end time of the surgery is before 16:00
Exclusion criteria
Exclusion criteria: 1. Previous diagnosis of sleep apnea syndrome, history of sleep disorders, or STOPBang score greater than or equal to 3 points; 2. Unable to communicate before surgery due to coma, severe dementia, language disorders, or serious illness; 3. Severe liver dysfunction (ChildePugh C-grade); Or require preoperative dialysis; 4. Weight100kg; 5. Patients refuse or are unable to use intravenous analgesia pumps; 6. Preoperative left ventricular ejection fraction<30%, severe arrhythmia, including preexcitation syndrome, pathological sinus syndrome, severe bradycardia (heart rate<50 beats per minute), or second or higher degree atrioventricular block without a pacemaker; 7. Lidocaine allergy patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative sleep disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sleep staging;HADs;Qor-15 postoperative recovery quality score;Opioid consumption at 24 hours after surgery/resting pain score and exercise pain score at 24 and 48 hours after surgery;Postoperative nausea and vomiting score;hospital stay;Time of first defecation and time of first exhaust; | — |
Countries
China
Contacts
Public ContactTao Luo
Peking University of Shenzhen Hospital
Outcome results
None listed