post stroke aphasia
Conditions
Interventions
Left hemisphere stimulation group:iTBS in the Left Broca area
Right hemisphere stimulation group:cTBS in the right Broca area
Bilateral hemisphere stimulation group:iTBS in the Left Broca area and cTBS in the right Broca area
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: The patient was diagnosed for the first time, meeting the diagnostic criteria for cerebral infarction or cerebral hemorrhage adopted by the Fourth National Conference on Cerebrovascular Diseases, and the lesion was confirmed by MRI examination to be located in the left cerebral hemisphere 2: Non-fluent aphasia was diagnosed by the western aphasia battery (WAB), and the course of disease was 1 month to 1 year 3: Patients aged 40 to 70 years 4: Students with primary school education or above were identified as right-handed by the handedness criteria of the Department of Neurology of the First Hospital of Beijing Medical University 5: Clear mind, stable condition, no serious cognitive dysfunction, mother tongue Mandarin Chinese, normal language and intelligence before onset 6: Can accept and cooperate with EEG, MRI examination and language and cognitive function evaluation
Exclusion criteria
Exclusion criteria: 1: Severe auditory, visual, writing, pronunciation and other sensory and motor organ damage caused by language, reading and writing disorders 2: Congenital or young diseases caused by learning difficulties, and caused by language deficits 3: Combined with epilepsy, serious heart, liver, kidney dysfunction or other serious physical diseases 4: Unconsciousness can not cooperate with the examination and treatment 5: Previous history of brain trauma, serious physical disease, alcohol and drug dependence or other diseases that may affect brain function and white matter fiber structure (such as: white matter fiber dystrophy, multiple sclerosis, acute sporadic encephalomyelitis, etc.) or other psychiatric and neurological diseases 6: There is a metal foreign body or other electronic device implanted in the body
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aphasia Quotien;Spontaneous speech;Auditory Comprehension;Repetition;Naming;dynamic amplitude of low-frequency fluctuations;dynamic functional connectivity; | — |
Countries
China
Contacts
Public ContactWang Hong
The First Affiliated Hospital of Jinan University
Outcome results
None listed